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Image Search Results
Journal: bioRxiv
Article Title: A subset of mouse hippocampus CA1 pyramidal neurons learns sparse synaptic input patterns
doi: 10.1101/2024.12.05.626959
Figure Lengend Snippet: (A) Brightfield (DIC + fluorescence) image of a hippocampal slice showing the anatomical regions CA1 and CA3, the location of the patch-clamp recording electrode (Patch), and the field recording site (Field) (B) DIC brightfield image of spatial light stimulation pattern in the CA3 region. LFP electrode location is indicated as Field , and the visible CA3 PN soma (contrast adjusted for better visibility). (Ci-Ciii) CA1 PN EPSPs in response to optogenetic stimulation of trained, overlapping, and non-overlapping input patterns respectively. Individual trial traces are shown in gray, and the trial-averaged response is shown in black. The dotted orange vertical line indicates the onset of optical stimulation. (Di-Diii) Field potential responses (mV) to optogenetic stimulation of trained, overlapping, and non-overlapping input patterns respectively. Individual trial traces are shown in gray, and the trial-averaged response is shown in black. The inset shows a magnified view of the initial 10 ms response. The dotted orange vertical line marks the onset of optical stimulation. (E) Violin plots comparing the variance in normalized EPSP and LFP responses. LFPs are much tighter. Statistical significance is indicated (**** p < 0.0001, with Levene’s test). (F) Optically stimulated LFP timings are precise and rapid compared to EPSPs (**** p < 0.0001, with Levene’s test). The red dashed line indicates the mean, and the red shading represents the standard deviation (σ in ms).
Article Snippet: The
Techniques: Fluorescence, Patch Clamp, Standard Deviation